Check out the writeup of Danielle and her work in the lab! Well-deserved spotlight, Danielle and Tyler!
And some more Deepta interviews re: the pandemic:
Tyler's article in Annual Review of Immunology is out! We review transcriptional and metabolic control of plasma cells and memory B lymphocytes. Please check it out to get our take on where the field is at and where we think it is going.
And the interviews continue:
And still more interviews:
And the interviews continue, including one for FiveThirtyEight (!):
Some more of Deepta's interviews on the virus, the pandemic, immunity, and vaccines:
Tyler's and Rachel's collaborative work is accepted by Immunity! Huge effort by many around UA to get this done. Protective SARS-CoV-2 antibodies persist for at least 5-7 months.
...And the news coverage continues--below is just a snippet:
Rachel's paper on ZBTB38 is accepted by PLoS One! You win some, you lose some in science. We couldn't find anything wrong with these knockout mice, but they are now available at MMRRC for others to try!
Kameron Peyton joins the lab as a research technician! Welcome, Kameron!
Rachel's paper is accepted by Immunity! Her study examines antibody responses to flaviviruses. Huge amount of work!
And, it is finally time (sniff). Rachel leaves the lab to take a great position at Vir Biotechnology. Not sure how the lab will manage without her, but we are so proud!!
Our slightly edgy and Bayesian commentary is accepted by The Journal of Immunology! Joint piece with Nicole Baumgarth, Janko Nikolich-Zugich, and Eun-Hyung Lee. Let's not throw away everything we have learned over decades of viral immunology!
The FDA grants emergency use authorization to the SARS-CoV-2 antibody test that the lab helped develop! Congrats, team!
Also, the insanity continues with news coverage. Check out Deepta's interview on NPR Science Fridays:
And more on Tyler's and Rachel's SARS-CoV-2 antibody work in collaboration with the Nikolich-Zugich lab:
Katye leaves the lab to take a position at Ventana Medical Systems. Stop stealing our people, Ventana! But seriously, congrats to Katye.
Hannah Newlin joins the lab as a research technician! Welcome, Hannah!
Bao Thai decides to join the lab as a MD-PhD student! Welcome Bao! He will begin in February, focusing on our stem cell projects.
And more news coverage--what a strange time to be immunologists! More links to coverage below:
Danielle Philo joins the lab as the group's first undergraduate student from UA! Welcome Danielle, and congrats on being admitted to UBRP! Danielle will be working with Tyler on clonal analysis of SARS-CoV-2 antibody responses.
Wow, what an insane few months! Lots of press for the Bhattacharya Lab and our efforts to develop a SARS-CoV-2 antibody test for the University and State. Here are a few links if you want to hear more:
Diana leaves the lab to take a position at Ventana. Congratulations, Diana!
Rachel successfully defends her thesis back at WashU!!! Congratulations, Rachel! Well-earned!
The lab's Juvenile Diabetes Research Foundation grant in collaboration with the NYSCF labs is renewed! This funding will allow us to continue our work to reverse Type 1 diabetes using grafts from minimally immunogenic pluripotent stem cells.
Arijita's paper is at long last accepted by Scientific Reports! In this study, we show that ZBTB32 restricts antibody responses to MCMV infections, but not to intestinal bacteria or influenza. Many thanks to the Hsieh, Yokoyama, Boon, and Kiela labs, and to Diana and Tyler for helping to close this out!
Ryan Wei joins the lab as a research technician; Katye Totten joins as a research specialist; Kelvin Pond joins as a postdoctoral fellow. Welcome everyone!!
Ian departs to begin graduate school at our old home of Washington University in St. Louis! We will miss you, Ian! Thanks for all the hard work and keeping the lab running smoothly!
Deepta is interviewed by Arizona Public Media/NPR! Check out the podcast to hear a quick blurb on the lab's work.
Review-o-rama concludes--Lucas' review on plasma cell metabolism is accepted! Soon to appear in Immunological Reviews.
The lab is awarded a grant from the Bill and Melinda Gates Foundation! The award supports our work on developing cellular therapies for infectious disease.
Rachel's review on memory B cell responses to infections is accepted!
Wing's paper is accepted by Cell Reports!! The manuscript reports the surprising finding that long- and short-lived plasma cells have almost no consistent transcriptional differences that distinguish them. Instead, metabolic properties are the major determinants of lifespan. Many thanks to Arijita, Lucas, Rachel, and members of the Meares and Patti labs at WVU and WashU for their help! Links to follow soon.
Tyler Ripperger joins as the lab's first UA PhD student! Welcome, Tyler!
The Bhattacharya Lab receives three grants from the NIH! The first R01 grant is a renewal of the lab's work on transcription factors that promote durable immunity, the second grant is a new R01 that focuses on metabolic pathways that control plasma cell antibody secretion and lifespan, and the final R21 grant funds our work on differentiating pluripotent stem cells into pathogen-specific plasma cells.
Diana Gerardo joins the lab as a research technician! Diana will be working on developing new anti-microbial antibodies.
Wing's and Deepta's review on plasma cells is published in Trends in Immunology!
Wing defends her thesis on metabolic pathways that control plasma cells!! Hooray! Wing will be moving back to her native California to begin a joint postdoc program at Amgen and Stanford University in Eugene Butcher's lab.
Kelly begins medical school at NYU! Congrats, Kelly!
The Bhattacharya Lab moves to the University of Arizona! Many thanks to Rachel, Hannah, and Lucas for braving the move. Special thanks to Krista for helping to set up the new lab before returning to St. Louis.
Ian McCabe joins the lab as a research technician! Ian did his undergrad at UA, and is an old hand at showing us the ropes on campus as well as new restaurants. Ian will be working on differentiation of pluripotent stem cells into effector immune lineages.
Arijita joins Milan Chheda's lab at Washington University in St. Louis. We wish you could have come with us, but we understand and wish you (and Anindya and Lily) the best in your new lab!
Lucas D'Souza joins the lab as a postdoctoral fellow. Welcome, Lucas!
Big news: The Bhattacharya Lab will be moving to the University of Arizona this summer to join the Department of Immunobiology! We will very much miss our friends and colleagues at WashU, but we are excited for the opportunity to join such a young and talented department. Stay tuned for more details...
Deepta is promoted to Associate Professor with tenure!! This is a tribute to all the members of the lab, past and present, whose hard work made this happen.
The lab receives a grant from the Juvenile Diabetes Research Foundation! This will fund collaborative work with the New York Stem Cell Foundation Labs to generate pluripotent stem cell-derived pancreatic beta cells that cannot be rejected.
The lab receives a supplemental award from the NIH! This will fund collaborative work with Gary Patti's group to look at metabolic pathways that regulate antibody-mediated immunity.
Derrick leaves to begin his graduate career at University of Pittsburgh. Good luck, Derrick!
Arijita's paper is accepted by the Journal of Immunology!! Her paper describes Zbtb32 as a novel negative regulator of the duration of memory B cell recall responses.
Wing's, Amy's, and Krista's paper is accepted by Immunity!! The manuscript details a metabolic pathway that maintains durable antibody-mediated immunity.
Kelly receives a BioSURF fellowship for the summer!
Amy's and Derrick's paper on GPR18 and intestinal intraepithelial lymphocytes is accepted by PLOS One! The work demonstrates that an orphan G protein-coupled receptor is important for restoring small intestinal intraepithelial lymphocytes after bone marrow transplantation.
Hannah Pizzato and Wing Lam join the lab as Ph.D. students!
Kelly Hu joins the lab as an undergraduate student!
Yinan moves to New York to begin a postdoctoral position. Yinan will be working with Barry Sleckman, a former colleague from WashU and an expert on DNA repair. Congratulations and good luck, Yinan!!
Yinan defends his thesis!!! Hooray, Yinan!
Rachel receives a predoctoral fellowship from the National Science Foundation! This is a highly prestigious award, where only ~14% of applicants are selected for funding.
Amy's paper is accepted by Experimental Hematology! Amy's paper describes the role of a metalloprotease, ADAM17, in regulating cytokine receptor expression on hematopoietic progenitors.
Amy moves to Boston to take an Instructor position at Harvard in Derrick Rossi's lab. The Rossi lab is a leader in the hematopoietic stem cell biology field, addressing questions of self-renewal and re-programming. Many thanks, Amy, for all the years of hard work, and good luck to the whole family!
Derrick Callahan joins the lab as a research technician. Welcome Derrick!
Rachel Wong joins the lab as a PhD student. Welcome, Rachel!
Amy's K01 is selected for funding, and she is offered a position in the lab of Derrick Rossi at Harvard!! Hooray, Amy!
Kranti will attend Johns Hopkins for medical school! Congratulations Kranti--you will be a great physician!
Yinan's paper is accepted by the Journal of Experimental Medicine! Congratulations, Yinan!! Yinan's paper shows that the transcription factor ZBTB20 regulates antibody responses in an adjuvant-specific manner.
The lab is awarded a grant from the American Cancer Society! The grant funds efforts to understand both plasma cell and multiple myeloma survival pathways.
Whitney joins the lab of Mark Anderson at UCSF. The Anderson lab is a leader in cellular and molecular pathways that lead to autoimmunity. Congratulations, Whitney! We will miss you!
Arijita Jash joins the lab as a postdoctoral fellow. Welcome, Ari!
Deepta is named a New York Stem Cell Foundation-Robertson Investigator (and gets to meet John McEnroe and Patty Smyth)! This grant funds our stem cell engineering work to generate targeted immune cells from embryonic stem cells.
The lab is awarded an R01 grant from the NIH!! This foundational grant funds work to understand the transcriptional networks which regulate durable antibody-mediated immunity.
Marilyn accepts a lab director position at Nestle-Purina. Congratulations Marilyn--we will miss you!
Krista Kennerly joins the lab as a research Technician. Welcome, Krista!
Whitney is awarded a W.M. Keck Fellowship! Congratulations, Whitney!!
Kranti Peddada joins the lab as an undergraduate researcher. Welcome, Kranti!
The lab is awarded a pilot grant from the Institute of Clinical and Translational Sciences! The grant funds work to identify molecular pathways which regulate antibody-mediated immunity.
Whitney's paper is accepted by PNAS! Congratulations, Whitney!! Whitney's paper identifies a spontaneous secondary mutation in the background of IRF5-/- mice, which is actually responsible for many of the reported phenotypes.
Amy's paper is accepted by Blood! Congratulations, Amy!! Amy's paper demonstrates that common transcriptional modules guide distinct hematopoietic progenitors into the same ultimate fate.
Whitney's paper is accepted by the Journal of Experimental Medicine! Congratulations, Whitney!! Whitney's paper demonstrates that long-lived plasma cells are effective at neutralizing pathogens which have been encountered earlier in life, whereas memory B cells deal with mutants of earlier encountered pathogens.
The lab is awarded a pilot grant from the Rheumatic Diseases Core Center! The grant funds work to identify pathways which allow autoreactive B cells to escape the germinal center reaction.
Whitney Purtha defends her PhD thesis and stays as a postdoctoral fellow. Congratulations, Whitney!
The lab is awarded a development grant from the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research! The grant funds work to identify memory B cells which counter mutant versions of West Nile and Dengue viruses.
The lab is awarded a grant from the Children's Discovery Institute! The grant funds work to study the role of memory B cells in countering influenza strains which vary from year-to-year.
Yinan is awarded a fellowship from the Siteman Cancer Center! Congratulations, Yinan!!
Amy Becker joins the lab as a postdoctoral fellow. Welcome Amy!
Yinan Wang joins the lab as a PhD student. Welcome Yinan!
The Bhattacharya Lab opens for business!
Marilyn Renner joins the lab as a research technician. Welcome, Marilyn!