Selected Publications

Ripperger T.J. and Bhattacharya D. "Transcriptional and Metabolic Control of Memory B Cells and Plasma Cells." Annu Rev Immunol, 2021, 39, 345-368.

Ripperger T.J.#, Uhrlaub J.L.#, Watanabe M.#, Wong R.#, Castaneda Y., Pizzato H.A., Thompson M.R., Bradshaw C., Weinkauf C.C., Bime C., Erickson H.L., Knox K., Bixby B., Parthasarathy S., Chaudhary S., Natt B., Cristan E., El Aini T., Rischard F., Campion J., Chopra M., Insel M., Sam A., Knepler J.L., Capaldi A.P., Spier C.M., Dake M.D., Edwards T., Kaplan M.E., Scott S.J., Hypes C., Mosier J., Harris D.T., Lafleur B.J., Sprissler R., Nikolich-Zugich J.##, and Bhattacharya D.## "Orthogonal SARS-CoV-2 serological assays enable surveillance of low prevalence communities and reveal durable humoral immunity." Immunity, 2020, online ahead of print

Wong R., Belk J.A., Govero J., Uhrlaub J.L., Reinartz D., Zhao H., Errico J.M., D’Souza L., Ripperger T.J., Nikolich-Zugich J., Shlomchik M.J., Satpathy A., Fremont D.H., Diamond M.S., and Bhattacharya D. "Affinity-restricted memory B cells dominate recall responses to heterologous flavivirus challenges." Immunity, 2020, online ahead of print

Baumgarth N., Nikolich-Zugich J., Lee F.E., and Bhattacharya D. "Antibody responses to SARS-CoV2: Let’s stick to the known knowns." Journal of Immunology, 2020, online ahead of print

Wong R. and Bhattacharya D., ZBTB38 is dispensable for antibody responses. PLoS One 2020: 15(9):e0235183

Jash A., Zhou Y.W., Gerardo D.K., Ripperger T.J., Parikh B.A., Piersma S., Jamwal D.R., Kiela P.R., Boon A.C.M., Yokoyama W.M., Hsieh C.S., and Bhattacharya D. "ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges." Scientific Reports, 2019, 9, 15257.

D’Souza L. and Bhattacharya D. "Plasma cells: You are what you eat." Immunol Rev, 2019, 288, 161-177

Wong R. and Bhattacharya D. "Basics of memory B-cell responses: lessons from and for the real world." Immunology, 2019, 156, 120-129.

Egawa T. and Bhattacharya D. "Regulation of metabolic supply and demand during B cell activation and subsequent differentiation." Curr Opin Immunol, 2019, 57, 8-14.

FXLam, W.Y., Jash, A.J., Yao, C., D'Souza, L., Wong, R., Nunley, R.N., Meares, G.P., Patti G.J., and Bhattacharya, D. "Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function". Cell Reports, 2018, 24, 2479-2492.

TREIMMLam W.Y. and Bhattacharya D. "Metabolic links between plasma cell survival, secretion, and stress." Trends Immunol, 2017, S1471-4906.

Immunity 2016Lam W.Y.*, Becker A.M.*, Kennerly K.M.*, Wong R., Curtis J.D., Llufrio E.M., McCommis K.S., Fahrmann J, Pizzato, H.A., Nunley R.M., Lee J., Wolfgang M.J., Patti G.J., Finck B.N., Pearce E.L., and Bhattacharya D. "Mitochondrial pyruvate import promotes the long-term survival of antibody-secreting plasma cells." Immunity, 2016, 45, 60-73.

Journal of Immunology 2016Jash A., Wang Y., Weisel F.J., Scharer C.D., Boss J.M., Shlomchik M.J., and Bhattacharya D., "ZBTB32 restricts the duration of memory B cell recall responses." J Immunol, 2016, 197, 1159-1168.

GPR18 2015Becker, A.M., Callahan, D.J., Richner, J.M., Choi, J., DiPersio, J.F., Diamond, M.S., and Bhattacharya, D. "GPR18 controls reconstitution of small intestine intraepithelial lymphocytes following bone marrow transplantation." PLoS One, 2015, 10, e0133854

Experimental Hematology Becker, A.M., Walcheck, B., and Bhattacharya, D. "ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors." Exp Hematol, 2015, 1, 44-52. 

Adjuvant-spcific regulation of long-term antibody responses by ZBTB20. Wang, Y. and Bhattacharya, D.  "Adjuvant-specific regulation of long-term antibody responses by ZBTB20."  J Exp Med, 2014, 211, 841-856. 

PNASPurtha, W.E., Swiecki, M., Colonna, M., Diamond, M.S., and Bhattacharya, D.  "Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses."  Proc Natl Acad Sci U S A, 2012, 109, E898-904. 

IRFBecker, A.M., Michael, D.G., Satpathy, A., Sciammas, R., Singh, H., and Bhattacharya, D.  "IRF-8 extinguishes neutrophil potential and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors."  Blood, 2012, 119, 2003-2012.

Memory B CellsPurtha, W.E., Tedder, T.F., Johnson, S., Bhattacharya, D.*, and Diamond, M.S.*  "Memory B cells but not long-lived plasma cells possess antigen specificities for viral escape mutants."  J Exp Med, 2011, 208, 2599-2606.

Niche RecyclingBhattacharya, D.*, Czechowicz, A.*, Ooi, A.G., Rossi, D.J., Bryder, D., and Weissman, I.L.  "Niche recycling through division-independent egress of hematopoietic stem cells."  J Exp Med 2009, 206, 2837-2850.

Ly6d marksInlay, M.A.*, Bhattacharya, D.*, Sahoo, D., Serwold, T., Seita, J., Karsunky, H., Plevritis, S.K., Dill, D.L., and Weissman, I.L.  "Ly6d marks the earliest stage of B cell specification and identifies the branchpoint between B and T cell development."  Genes Dev, 2009, 23, 2376-2381.

Space-time considerations for hematopoietic stem cell transplantation.Bhattacharya, D., Ehrlich, L.I., and Weissman, I.L.  "Space-time considerations for hematopoietic stem cell transplantation."  Eur J Immunol.  2008, 38, 2060-2067.

ScienceCzechowicz, A., Kraft, D., Weissman, I.L.*, and Bhattacharya, D.* "Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches." Science 2007, 318, 1296-1299.

ImmunologyBhattacharya, D., Cheah, M.T., Franco, C.B., Pin, C.L., Sha, W.C., and Weissman, I.L. "Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation."  J Immunol 2007, 179, 6808-6819.  

Purified hematopoietic stem cellBhattacharya, D., Rossi, D.J., Bryder, D., and Weissman, I.L.  "Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies in unconditioned hosts."  J Exp Med 2006, 203, 73-85.

PNAS MemoryLuckey, C.J.*, Bhattacharya, D.*, Goldrath, A.W.*, Weissman, I.L., Benoist, C., and Mathis, D.  "Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells."  Proc Natl Acad Sci U S A 2006, 103, 3304-9.

cell cycleBhattacharya, D.*, Bryder, D.*, Rossi, D.J., and Weissman, I.L.  "Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors."  Cell Cycle 2006, 5, 1135-1139.

PNAS GeneBhattacharya, D., Logue, E.C., Bakkour, S., Degregori, J., and Sha, W.C.  "Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries."  Proc Natl Acad Sci U S A 2002, 99, 8838-8843.

RetroviralBhattacharya, D., Lee, D.U., and Sha, W.C.  “NF-kB-mediated regulation of isotype switching:  Retroviral expression of RelB specifically inhibits class switch recombination to IgG1, but not to IgE.”  Int Immunol  2002, 14, 983-991.

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